Quick Answer: Explain How Manipulation Of These Factors Can Increase Toxicity?

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What are the factors that affect toxicity?

What Factors Influence Toxic Exposure Levels?

  • Point Of Entry. A substance can only affect a person or animal by coming into physical contact with the body.
  • Dosage and Toxicity. These are perhaps the two most important factors determining the hazard presented by any given substance.
  • Rate Of Removal.
  • Biological Variation.

Which factor can affect the distribution of a toxicant in the body?

The distribution of toxicants and toxic metabolites throughout the body ultimately determines the sites where toxicity occurs. A major determinant of whether or not a toxicant will damage cells is its lipid solubility. If a toxicant is lipid-soluble it readily penetrates cell membranes.

What are four factors that determine toxicity level?

When you inhale a toxic chemical, the dose you receive depends on four factors: (1) the level (concentration) of chemical in the air; (2) how hard (fast and deep) you are breathing, which depends on your degree of physical exertion; (3) how much of the chemical that is inhaled stays in your lungs and is absorbed into

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How does toxicity develop?

Toxicity of a substance can be affected by many different factors, such as the pathway of administration (whether the toxicant is applied to the skin, ingested, inhaled, injected), the time of exposure (a brief encounter or long term), the number of exposures (a single dose or multiple doses over time), the physical

What are signs of toxicity?

General symptoms of poisoning can include:

  • feeling and being sick.
  • diarrhoea.
  • stomach pain.
  • drowsiness, dizziness or weakness.
  • high temperature of 38C (100.4F) or above.
  • chills (shivering)
  • loss of appetite.
  • headache.

What is the highest level of toxicity?

Category 1, the highest toxicity category, has cut off values of 5 mg/kg by the oral route, 50 mg/kg by the dermal route, 100 ppm for gases or gaseous vapours, 0.5 mg/l for vapours, and 0.05 mg/l for dusts and mists.

What are the three major ways for the removal of toxicant from body?

Toxicants are removed from the systemic circulation by biotransformation, excretion, and storage at various sites in the body. Excretion is the removal of xenobiotics from the blood and their return to the external environment via urine, feces, exhalation, etc.

What factors contribute to the effect an environmental toxin have on the human body?

Environmental factors, such as temperature, humidity, and barometric pressure, affect rates of consumption and even the occurrence of some toxic agents. Many mycotoxins and poisonous plants are correlated with seasonal or climatic changes.

Which one of the following are the main targets of lead toxicity?

Lead is a highly poisonous metal affecting almost every organ in the body. Of all the organs, the nervous system is the mostly affected target in lead toxicity, both in children and adults.

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What are the three main factors that influence toxicity?

Toxicity of chemicals is greatly affected by various factors pertaining to their exposures to the organisms. Some of the important factors related to exposures are: (i) exposure routes, (ii) exposure duration, and (iii) exposure systems.

How do you test for toxicity in the body?

Heavy metal toxicity is diagnosed by means of an evaluation of symptoms and testing for heavy metal levels. A heavy metals test may look for specific metals in urine, blood, or plasma to evaluate levels within the body. Your blood sample can be used to check mercury levels or diagnose lead poisoning, for example.

What are examples of toxins?

Toxins from Bacteria

  • Anthrax lethal toxin is produced by Bacillus anthracis.
  • Botulinum toxin, produced by Clostridium botulinum, is one of the most poisonous substance known.
  • Pertussis toxin is produced by the Bordetella pertussis bacteria which causes whooping cough.

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